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NPD-1335

Product Specifications

CAS Number

2376326-31-5

Target

Parasite, Others, PDE

Related Pathways

Others, Metabolism, Microbiology/Virology

Bioactivity

NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels, NPD1335 disrupts the cell cycle, leading to cell death [1].

Smiles

[H][C@]12CC=CC[C@@]1([H])C(=NN(C(C)C)C2=O)c1ccc(OC)c(c1)C#CC(=O)NCc1ccccc1

Molecular Formula

C28H29N3O3

Molecular Weight

455.55

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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