MRK-016
Product Specifications
CAS Number
342652-67-9
Target
GABA Receptor
Related Pathways
Membrane transporter/Ion channel|||Neuroscience
Purity
0.9976
Bioactivity
MRK-016 is a selective GABAA ?5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects.
Smiles
N=1N=C(C2=NOC(=C2)C)N3N=C(OCC4=NC=NN4C)C(=C3C1)C(C)(C)C
Molecular Formula
C17H20N8O2
Molecular Weight
368.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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