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MMAF-OMe

Product Specifications

CAS Number

863971-12-4

Target

ADC Cytotoxin

Related Pathways

Antibody-drug Conjugate/ADC Related

Purity

0.9934

Bioactivity

MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.

Smiles

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C

Molecular Formula

C40H67N5O8

Molecular Weight

745.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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