ML218
Product Specifications
CAS Number
1346233-68-8
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism
Purity
0.9945
Bioactivity
ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively) .ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN) .
Smiles
[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
Molecular Formula
C19H26Cl2N2O
Molecular Weight
369.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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