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ML218

Product Specifications

CAS Number

1346233-68-8

Target

Calcium Channel

Related Pathways

Membrane transporter/Ion channel|||Metabolism

Purity

0.9945

Bioactivity

ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively) .ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN) .

Smiles

[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1

Molecular Formula

C19H26Cl2N2O

Molecular Weight

369.33

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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