Metarrestin
Product Specifications
CAS Number
1443414-10-5
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9945
Bioactivity
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
Smiles
O[C@H]1CC[C@@H](CC1)n1cnc2n(Cc3ccccc3)c(c(-c3ccccc3)c2c1=N)-c1ccccc1
Molecular Formula
C31H30N4O
Molecular Weight
474.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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