Lys-SMCC-DM1

Product Specifications

CAS Number

1281816-04-3

Target

Microtubule Associated|||Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related|||Cytoskeletal Signaling

Purity

?98%

Bioactivity

Lys-SMCC-DM1 (Lys-N?-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2) . It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.

Smiles

C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS[C@@H]5C(=O)N(C[C@@H]6CC[C@@H](C(NCCCC[C@@H](C(O)=O)N)=O)CC6)C(=O)C5)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]