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LV-320

Product Specifications

CAS Number

2449093-46-1

Target

Autophagy, Cysteine Protease

Related Pathways

Proteases/Proteasome, Autophagy

Bioactivity

LV-320 is a potent, uncompetitive ATG4B inhibitor with an IC50 of 24.5 μM and a Kd of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].

Smiles

OC(=O)CCSC(SCCc1ccccc1)c1ccc(\C=C\c2ccnc3cc(Cl)ccc23)cc1

Molecular Formula

C29H26ClNO2S2

Molecular Weight

520.11

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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