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LTβR-IN-1

Product Specifications

CAS Number

2189366-77-4

Target

NF-κB, LTR

Related Pathways

Immunology/Inflammation, NF-κB

Purity

0.9909

Bioactivity

LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor with a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, without affecting the nuclear translocation of p65 mediated by the TNF-α receptor. It inhibits p52 nuclear translocation stimulated by TWEAK or Anti-LTβR with an IC50 of 10 μM and regulates the NF-kB signaling pathway in a ligand-independent manner.

Smiles

C[C@@H](N1Cc2ccccc2C1=O)C(=O)Nc1nc2ccccc2[nH]1

Molecular Formula

C18H16N4O2

Molecular Weight

320.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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