LT?R-IN-1
Product Specifications
CAS Number
2189366-77-4
Target
NF-?B|||LTR
Related Pathways
Immunology/Inflammation|||NF-?B
Purity
0.9909
Bioactivity
LT?R-IN-1 is a potent and selective lymphin ? receptor (LT?R) inhibitor with a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, without affecting the nuclear translocation of p65 mediated by the TNF-? receptor. It inhibits p52 nuclear translocation stimulated by TWEAK or Anti-LT?R with an IC50 of 10 ?M and regulates the NF-kB signaling pathway in a ligand-independent manner.
Smiles
C[C@@H](N1Cc2ccccc2C1=O)C(=O)Nc1nc2ccccc2[nH]1
Molecular Formula
C18H16N4O2
Molecular Weight
320.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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