Leptomycin A
Product Specifications
CAS Number
87081-36-5
Target
HIV Protease, CRM1, Antibiotic
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Membrane transporter/Ion channel
Bioactivity
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.
Smiles
C[C@H](C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O)\C=C(\C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C
Molecular Formula
C32H46O6
Molecular Weight
526.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
131744-ML750 100 µL
PRDM1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, BLIMP1) (MaxLight 750) discontinued
Sign In for Pricing
View Details 
E8489-05A 200 µL
ETHE1, ID (Protein ETHE1, Mitochondrial, Ethylmalonic Encephalopathy Protein 1, Hepatoma Subtracted Clone One Protein, HSCO)
Sign In for Pricing
View Details 
GTR15163001 1 Vial
Lentiviral human FADS2 shRNA (UAS) - Lentiviral human FADS2 shRNA (UAS) (25)
Sign In for Pricing
View Details