Leptomycin A
Product Specifications
CAS Number
87081-36-5
Target
HIV Protease, CRM1, Antibiotic
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Membrane transporter/Ion channel
Bioactivity
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.
Smiles
C[C@H](C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O)\C=C(\C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C
Molecular Formula
C32H46O6
Molecular Weight
526.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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