Propoxur

Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3].

Product Specifications

CAS Number

[114-26-1]

UNSPSC

12352005

Hazard Statement

H300+H330, H311

Target

Cholinesterase (ChE) ; ERK; Insecticide; Keap1-Nrf2; MMP; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Propoxur.html

Concentration

10mM

Purity

99.43

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)OC1=CC=CC=C1OC(NC)=O

Molecular Formula

C11H15NO3

Molecular Weight

209.24

Precautions

H300+H330, H311

References & Citations

[1]Shi Y, et al. Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway. Oncotarget. 2017 Jul 7;8 (50) :87107-87123.|[2]Maran E, et al. Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHO-K1 cells. Food Chem Toxicol. 2010 Jun;48 (6) :1592-6.|[3]Mohamadin A M, et al. Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions[J]. Pesticide biochemistry and physiology, 2010, 98 (1) : 128-134.