Eltanexor
Product Specifications
CAS Number
1642300-52-4
Target
CRM1, Others
Related Pathways
Others, Membrane transporter/Ion channel
Purity
0.9986
Bioactivity
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
Smiles
NC(=O)C(=C\n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1
Molecular Formula
C17H10F6N6O
Molecular Weight
428.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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