KDOAM-25 citrate
Product Specifications
CAS Number
2448475-08-7
Target
Others, Histone Demethylase
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor, with IC50 values of 71 nM, 19 nM, 69 nM, and 69 nM for KDM5A, KDM5B, KDM5C, and KDM5D, respectively. Multiple myeloma MM1S cells treated with KDOAM-25 citrate show increased global H3K4 methylation at transcriptional start sites and impaired proliferation [1].
Smiles
NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.OC(CC(C(O)=O)(O)CC(O)=O)=O
Molecular Formula
C21H33N5O9
Molecular Weight
499.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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