JBJ-04-125-02
Product Specifications
CAS Number
2060610-53-7
Target
JAK|||EGFR
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors
Bioactivity
JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.
Smiles
[C@@H](C(NC1=NC=CS1)=O)(N2C(=O)C=3C(C2)=CC=C(C3)C4=CC=C(C=C4)N5CCNCC5)C6=C(O)C=CC(F)=C6
Molecular Formula
C29H26FN5O3S
Molecular Weight
543.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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