Jaspamycin
Product Specifications
CAS Number
22242-96-2
Target
Parasite, JAK, PKA
Related Pathways
Stem Cells, JAK/STAT signaling, Microbiology/Virology, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα but exhibits anti-parasite activity and is a potent activator of PKA, binding to the R site (PKAR) with an EC50 of 6.5 nM and a Kd of 8 nM in Trypanosoma brucei.
Smiles
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#N)c2c1nc[nH]c2=O
Molecular Formula
C12H12N4O5
Molecular Weight
292.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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