JAK3 covalent inhibitor-1
Product Specifications
CAS Number
2300106-50-5
Target
JAK
Related Pathways
Angiogenesis, Stem Cells, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.
Smiles
N(C#N)[C@@H]1C=2C([C@H](NS(=O)(=O)C3=CC(F)=CC=C3)C1)=CC=C(C2)C4=C5C(=NC=N4)NC=C5
Molecular Formula
C22H17FN6O2S
Molecular Weight
448.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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