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J-113863

Product Specifications

CAS Number

353791-85-2

Target

CCR

Related Pathways

Microbiology/Virology, GPCR/G Protein, Immunology/Inflammation

Purity

0.9511

Bioactivity

J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM), but a weak antagonist of the mouse CCR3 (IC50 of 460 nM) . J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.

Smiles

[I-].CC[N+]1(C\C2=C\CCCCCC2)CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12

Molecular Formula

C30H37Cl2IN2O2

Molecular Weight

655.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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