INT-777
Product Specifications
CAS Number
1199796-29-6
Target
GPCR19
Related Pathways
GPCR/G Protein
Purity
0.9989
Bioactivity
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 ?M. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
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[H][C@@]12CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])[C@H](O)[C@H](CC)[C@]2([H])C[C@H](O)CC[C@]12C
Molecular Formula
C27H46O5
Molecular Weight
450.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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