Ilorasertib hydrochloride
Product Specifications
CAS Number
1847485-91-9
Target
PDGFR, VEGFR, Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Angiogenesis, Chromatin/Epigenetic
Purity
0.9845
Bioactivity
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM) . It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM) .
Smiles
Cl.Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Molecular Formula
C25H22ClFN6O2S
Molecular Weight
525
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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