IDH1 Inhibitor 2

2244895-42-7

Isocitrate Dehydrogenase (IDH), Dehydrogenase

Metabolism

IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor through direct covalent modification of His315, with an IC50 of 110 nM.

C[C@H]1[C@]2([C@@](C=3C(CC2)=CN=C(NC4=CC=CC=C4)N3)(C=C(C#N)C1=O)C5=CC=CC=C5)[H]

C26H22N4O

406.48

Ice Packs

-20°C