ICA-105665
Product Specifications
CAS Number
2694728-63-5
Target
Potassium Channel, Others
Related Pathways
Membrane transporter/Ion channel, Others
Bioactivity
ICA-105665 (PF-04895162) is a potent and orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM) . ICA-105665 can penetrate the central nervous system (CNS) and has antiseizure effects [1][2][3][4].
Smiles
N(C(CC1=CC=C(F)C=C1)=O)N2C(=NC=3C(C2=O)=CC=C(F)C3)C4CC4
Molecular Formula
C19H15F2N3O2
Molecular Weight
355.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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