HKI-357
Product Specifications
CAS Number
848133-17-5
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9991
Bioactivity
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Smiles
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1381350-01 0.02 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details MBS1381350-02 0.02 mg (Yeast)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details MBS1381350-03 0.1 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details MBS1381350-04 0.1 mg (Yeast)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details MBS1381350-05 0.02 mg (Baculovirus)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details MBS1381350-06 0.02 mg (Mammalian-Cell)
Recombinant Escherichia coli O157:H7 Protein frlC (frlC)
Sign In for Pricing
View Details