HG-12-6
Product Specifications
CAS Number
2222354-57-4
Target
Others, IRAK
Related Pathways
Immunology/Inflammation, NF-κB, Others
Bioactivity
HG-12-6 is a type II inhibitor of IRAK4, demonstrating preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM) and modulating IRAK4 activity in autoimmunity and inflammation.
Smiles
N(C(=O)C1CC1)C=2SC=3C(N2)=CC=C(N3)C4=CC(C(NC5=CC(C(F)(F)F)=C(CN6CCNCC6)C=C5)=O)=CC=C4
Molecular Formula
C29H27F3N6O2S
Molecular Weight
580.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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