HG-12-6

Product Specifications

CAS Number

2222354-57-4

Target

Others|||IRAK

Related Pathways

Immunology/Inflammation|||NF-?B|||Others

Bioactivity

HG-12-6 is a type II inhibitor of IRAK4, demonstrating preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM) and modulating IRAK4 activity in autoimmunity and inflammation.

Smiles

N(C(=O)C1CC1)C=2SC=3C(N2)=CC=C(N3)C4=CC(C(NC5=CC(C(F)(F)F)=C(CN6CCNCC6)C=C5)=O)=CC=C4

Molecular Formula

C29H27F3N6O2S

Molecular Weight

580.62

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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