GSK-843
Product Specifications
CAS Number
1601496-05-2
Target
Apoptosis, RIP kinase
Related Pathways
NF-κB, Apoptosis
Purity
0.9918
Bioactivity
GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
Smiles
Cc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1
Molecular Formula
C19H15N5S2
Molecular Weight
377.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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