GNE684
Product Specifications
CAS Number
2438637-64-8
Target
TNF, RIP kinase
Related Pathways
Apoptosis, NF-κB
Bioactivity
GNE684 is a potent inhibitor of receptor interacting protein 1 (RIP1) with average Ki app values of 21 nM for human, 189 nM for mouse, and 691 nM for rat RIP1, respectively [1].
Smiles
C(N[C@@H]1C(=O)N(C)C=2C(CC1)=CC(OC)=NC2)(=O)C3=NN4[C@@H](CCC4=N3)C5=CC=CC=C5
Molecular Formula
C23H24N6O3
Molecular Weight
432.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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