GNE-0439
Product Specifications
CAS Number
1241902-40-8
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.996
Bioactivity
GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.
Smiles
C(N[C@@H]([C@@H](C)C)C(O)=O)(=O)C1=CC=C(C=C1)C2CCC(CCC)CC2
Molecular Formula
C21H31NO3
Molecular Weight
345.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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