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GCN2-IN-6

Product Specifications

CAS Number

2183470-09-7

Target

PERK

Related Pathways

Apoptosis

Purity

0.98

Bioactivity

GCN2-IN-6 is a potent and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50: 1.8 nM) and cellular assays (IC50: 9.3 nM) . GCN2-IN-6 is also an eIF2? kinase PERK inhibitor with IC50s of 0.26 nM in enzymatic assay and 230 nM in cells respectively.

Smiles

Nc1ncc(cn1)C#Cc1c(F)ccc(NS(=O)(=O)c2cc(Cl)cc(CO)c2Cl)c1F

Molecular Formula

C19H12Cl2F2N4O3S

Molecular Weight

485.29

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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