Ganodermanontriol
Product Specifications
CAS Number
106518-63-2
Target
Others, CDK, Wnt/beta-catenin
Related Pathways
Cell Cycle/Checkpoint, Stem Cells, Others, Cytoskeletal Signaling
Purity
0.9997
Bioactivity
Ganodermanontriol is a purified triterpene extracted from GL that inhibits proliferation of HCT-116 and HT-29 colon cancer cells without significantly compromising cell viability and suppresses β-catenin transcriptional activity and cyclin D1 protein levels in a dose-dependent manner. Ganodermanontriol also reduces Cdk-4 and PCNA while increasing E-cadherin and β-catenin accumulation in HT-29 cells, Ganodermanontriol markedly suppresses tumor growth in an HT-29 xenograft mouse model without adverse effects, highlighting its strong potential as a chemotherapeutic candidate for colorectal cancer research.
Smiles
C[C@@]12C=3C([C@@]4(C)[C@](C)(CC3)[C@@]([C@@H](CC[C@@H]([C@](CO)(C)O)O)C)(CC4)[H])=CC[C@]1(C(C)(C)C(=O)CC2)[H]
Molecular Formula
C30H48O4
Molecular Weight
472.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
243961-APC 100 µL
C14orf129 (Chromosome 14 Open Reading Frame 129, GSKIP, HSPC210, MGC4945) (APC)
Sign In for Pricing
View Details ![Mouse Monoclonal Proliferation Marker Antibody (JC1) [DyLight 650]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP3-08342C 100 µL
Mouse Monoclonal Proliferation Marker Antibody (JC1) [DyLight 650]
Sign In for Pricing
View Details GTR15111571 1 Vial
Lentiviral human ARHGAP29 shRNA (UAS) - Lentiviral human ARHGAP29 shRNA (UAS) plasmid
Sign In for Pricing
View Details