Ganodermanontriol
Product Specifications
CAS Number
106518-63-2
Target
Others|||CDK|||Wnt/beta-catenin
Related Pathways
Cell Cycle/Checkpoint|||Stem Cells|||Others|||Cytoskeletal Signaling
Purity
0.9997
Bioactivity
Ganodermanontriol is a purified triterpene extracted from GL that inhibits proliferation of HCT-116 and HT-29 colon cancer cells without significantly compromising cell viability and suppresses ?-catenin transcriptional activity and cyclin D1 protein levels in a dose-dependent manner. Ganodermanontriol also reduces Cdk-4 and PCNA while increasing E-cadherin and ?-catenin accumulation in HT-29 cells, Ganodermanontriol markedly suppresses tumor growth in an HT-29 xenograft mouse model without adverse effects, highlighting its strong potential as a chemotherapeutic candidate for colorectal cancer research.
Smiles
C[C@@]12C=3C([C@@]4(C)[C@](C)(CC3)[C@@]([C@@H](CC[C@@H]([C@](CO)(C)O)O)C)(CC4)[H])=CC[C@]1(C(C)(C)C(=O)CC2)[H]
Molecular Formula
C30H48O4
Molecular Weight
472.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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