Furamidine
Product Specifications
CAS Number
73819-26-8
Target
Parasite, Histone Methyltransferase, PDE, Others
Related Pathways
Others, Metabolism, Chromatin/Epigenetic, Microbiology/Virology
Bioactivity
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively) . Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA.
Smiles
C(=N)(N)C1=CC=C(C=2OC(=CC2)C3=CC=C(C(=N)N)C=C3)C=C1
Molecular Formula
C18H16N4O
Molecular Weight
304.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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