Forodesine hydrochloride
Product Specifications
CAS Number
284490-13-7
Target
Apoptosis|||Nucleoside Antimetabolite/Analog|||Others
Related Pathways
Cell Cycle/Checkpoint|||Others|||DNA Damage/DNA Repair|||Apoptosis
Bioactivity
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
Smiles
Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O
Molecular Formula
C11H15ClN4O4
Molecular Weight
302.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15300694 1 Vial
Lentiviral mouse Itih1 shRNA (UAS) - Lentiviral mouse Itih1 shRNA (UAS) plasmid
Ask
View Details GTR15119673 1 Vial
Lentiviral human UPF3A shRNA (UAS) - Lentiviral human UPF3A shRNA (UAS, GFP) (100)
Ask
View Details 
MBS2136303-01 0.1 mL
APC Linked Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3)
Ask
View Details 
MBS2136303-02 0.2 mL
APC Linked Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3)
Ask
View Details MBS2136303-03 0.5 mL
APC Linked Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3)
Ask
View Details