FMF-04-159-2
Product Specifications
CAS Number
2364489-81-4
Target
Others, CDK, Wnt/beta-catenin
Related Pathways
Cell Cycle/Checkpoint, Stem Cells, Others, Cytoskeletal Signaling
Purity
0.9657
Bioactivity
FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC50 of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.
Smiles
N(C(=O)C1=C(Cl)C=C(Cl)C=C1Cl)C=2C(C(NC3CCN(S(=O)(=O)C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)CC3)=O)=NNC2
Molecular Formula
C28H30Cl3N7O5S
Molecular Weight
683.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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