FM26
Product Specifications
CAS Number
2407981-35-3
Target
ROR
Related Pathways
Metabolism
Bioactivity
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM.
Smiles
C(NC1=CC=C(C(O)=O)C=C1)C=2C(=NOC2C=3C=CNC3)C4=C(C(F)(F)F)C=CC=C4Cl
Molecular Formula
C22H15ClF3N3O3
Molecular Weight
461.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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