FM26

Product Specifications

CAS Number

2407981-35-3

Target

ROR

Related Pathways

Metabolism

Bioactivity

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor ?t (ROR?t) inverse agonists with an IC50 of 264 nM.

Smiles

C(NC1=CC=C(C(O)=O)C=C1)C=2C(=NOC2C=3C=CNC3)C4=C(C(F)(F)F)C=CC=C4Cl

Molecular Formula

C22H15ClF3N3O3

Molecular Weight

461.82

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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