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FKBP12 PROTAC dTAG-7

Product Specifications

CAS Number

2064175-32-0

Target

Epigenetic Reader Domain, PROTACs, FKBP

Related Pathways

Immunology/Inflammation, Chromatin/Epigenetic, Autophagy, Apoptosis, PROTAC

Bioactivity

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.

Smiles

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCOCCOCCOCCCNC(COC4=C([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)C=CC=C4)=O)=O

Molecular Formula

C63H79N5O19

Molecular Weight

1210.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Frequently Asked Questions

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