FKBP12 PROTAC dTAG-7
Product Specifications
CAS Number
2064175-32-0
Target
Epigenetic Reader Domain|||PROTACs|||FKBP
Related Pathways
Immunology/Inflammation|||Chromatin/Epigenetic|||Autophagy|||Apoptosis|||PROTAC
Bioactivity
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCOCCOCCOCCCNC(COC4=C([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)C=CC=C4)=O)=O
Molecular Formula
C63H79N5O19
Molecular Weight
1210.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/0999BFFA-1CE6-4CA5-B720-BA9C16F4DF94/T11292
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