FGTI-2734
Product Specifications
CAS Number
1247018-19-4
Target
Kras, Ras, Transferase
Related Pathways
Metabolism, MAPK
Purity
0.9969
Bioactivity
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors.
Smiles
Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cc1F)C#N
Molecular Formula
C26H31FN6O2S
Molecular Weight
510.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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