EP4 receptor antagonist 1
Product Specifications
CAS Number
2287259-07-6
Target
Prostaglandin Receptor
Related Pathways
Immunology/Inflammation, GPCR/G Protein
Purity
0.9953
Bioactivity
EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and 16.2 nM, respectively, while displaying minimal activity (IC50s >10 μM) against human EP1, EP2, and EP3 receptors.
Smiles
C\C=C\c1nnn(Cc2ccc(cc2)C(F)(F)F)c1C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O
Molecular Formula
C23H21F3N4O3
Molecular Weight
458.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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