EN6
Product Specifications
CAS Number
1808714-73-9
Target
Proton pump, Autophagy
Related Pathways
Autophagy, Membrane transporter/Ion channel
Purity
0.9704
Bioactivity
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase) .
Smiles
Fc1ccc(NC(=O)c2cnn(c2)-c2ccccc2F)cc1NC(=O)C=C
Molecular Formula
C19H14F2N4O2
Molecular Weight
368.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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