EGFR mutant-IN-1

Product Specifications

Target

EGFR

Related Pathways

Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Bioactivity

EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect.

Smiles

O=C1C(C2=CC=CC(F)=C2Cl)=C(C)C3=CN=C(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)N=C3N1[C@H]6CN(C(CC)=O)CCC6

Molecular Formula

C34H39ClFN7O2

Molecular Weight

632.17

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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