EGFR-IN-11

Product Specifications

CAS Number

2463200-44-2

Target

Apoptosis|||EGFR

Related Pathways

Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Purity

0.9993

Bioactivity

EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

Smiles

CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1

Molecular Formula

C29H35N9O2S

Molecular Weight

573.71

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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