EGFR-IN-11
Product Specifications
CAS Number
2463200-44-2
Target
Apoptosis|||EGFR
Related Pathways
Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Purity
0.9993
Bioactivity
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.
Smiles
CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1
Molecular Formula
C29H35N9O2S
Molecular Weight
573.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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