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EB-47

Product Specifications

CAS Number

366454-36-6

Target

PARP

Related Pathways

DNA Damage/DNA Repair|||Chromatin/Epigenetic

Purity

0.9986

Bioactivity

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

Smiles

O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C(=O)N4CCN(CC(NC5=C6C(C(=O)NC6)=CC=C5)=O)CC4)[C@H]1O

Molecular Formula

C24H27N9O6

Molecular Weight

537.53

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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