Duocarmycin SA
Product Specifications
CAS Number
130288-24-3
Target
DNA Alkylator/Crosslinker, Apoptosis, Necroptosis, ADC Cytotoxin, Antibiotic
Related Pathways
DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related, Apoptosis, Microbiology/Virology
Bioactivity
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
Smiles
C(=O)(N1C=2[C@]3([C@](C3)(C1)[H])C4=C(NC(C(OC)=O)=C4)C(=O)C2)C=5NC=6C(C5)=CC(OC)=C(OC)C6OC
Molecular Formula
C25H23N3O7
Molecular Weight
477.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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