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DRI-C21045

Product Specifications

CAS Number

2101765-81-3

Target

NF-κB, TNF

Related Pathways

NF-κB, Apoptosis

Purity

0.981

Bioactivity

Dri-c21045 showed concentration-dependent inhibition of NF-kB activation and all CD40L induced by B cell proliferation with IC50 of 17.1 μM and 4.5 μM, respectively. Dri-c21045 is an effective selective inhibitor of CD40-CD40L synergistic stimulator protein-protein interaction (PPI) with IC50 of 0.17 μM.

Smiles

COC(=O)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1cccc2cccc(c12)S(O)(=O)=O

Molecular Formula

C32H24N2O7S

Molecular Weight

580.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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