Dooku1
Product Specifications
CAS Number
2253744-54-4
Target
Piezo Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9974
Bioactivity
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC) . Dooku1 inhibits Yoda1-induced aortic relaxation.
Smiles
Clc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1
Molecular Formula
C13H9Cl2N3OS
Molecular Weight
326.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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