DLK-IN-1
Product Specifications
CAS Number
1620574-24-4
Target
MAPK, DNA Alkylation
Related Pathways
MAPK, DNA Damage/DNA Repair
Bioactivity
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration exceeds the concentration required for DLK inhibition in the brain, so it has good tolerance Acceptability.
Smiles
[H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1
Molecular Formula
C20H24F3N5O2
Molecular Weight
423.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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