α-Solanine

α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells[1].

Product Specifications

CAS Number

[20562-02-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; Apoptosis; Autophagy; COX; MMP; mTOR; NF-κB; NO Synthase

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/α-solanine.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](N4[C@@](CC[C@H](C)C4)([H])[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@@H](O)[C@@H](CO)O7)O[C@]8([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC6)=CC5)C)([H])CC2

Molecular Formula

C45H73NO15

Molecular Weight

868.06

Precautions

H302

References & Citations

[1]Lei Wang , et al. Inhibitory Effect of α-Solanine on Esophageal Carcinoma in vitro. Exp Ther Med. 2016 Sep;12 (3) :1525-1530.|[2]Gu T, et al., α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo. Toxins (Basel) . 2021 Mar 13;13 (3) :210. |[3]Shin JS, et al., α-Solanine Isolated From Solanum Tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Responses Via NF-κB Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice. J Cell Biochem. 2016 Oct;117 (10) :2327-39.|[4]Hasanain M, et al., α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Cell Death Dis. 2015 Aug 27;6 (8) :e1860.